The FAP Research Initiative funds innovative research to improve outcomes for individuals with Familial Adenomatous Polyposis (FAP)—a rare, inherited syndrome caused by pathogenic germline variants in the APC gene and marked by early-onset colorectal polyposis and markedly elevated digestive cancer risk. With only limited treatment and prevention options for FAP patients, more research is needed to improve lives of FAP patients and their families.

We support basic, translational, and clinical research aimed at advancing diagnostics, early detection, prevention, and therapeutic options for FAP. Our goal is to expand the evidence base, accelerate clinical impact, and ultimately improve quality of life for patients and families affected by this condition.

The FAP Research Initiative is a project of the Roxanne and Henry Brandt Foundation in collaboration with the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC). The CGA-IGC is a leading network of clinicians and scientists focused on hereditary gastrointestinal cancer syndromes.

Together, we aim to catalyze meaningful progress in a historically underfunded field.